CJC-1295 (no DAC)
🔬 Overview
CJC-1295 without DAC (also called Modified GRF 1-29 or Mod GRF 1-29) is a 29 amino acid analogue of endogenous growth hormone releasing hormone (GHRH). The four amino acid substitutions (at positions 2, 8, 15, and 27) improve stability against enzymatic degradation, extending the half-life from ~7 minutes (native GHRH) to approximately 30 minutes.
By mimicking GHRH, CJC-1295 (no-DAC) stimulates the pituitary to release growth hormone in a pulsatile pattern. Unlike CJC-1295 with DAC (Drug Affinity Complex), the no-DAC version produces discrete GH pulses rather than continuous elevation — preserving the natural pulsatile rhythm that appears important for GH receptor sensitivity.
CJC-1295 (no-DAC) is predominantly studied in combination with Ipamorelin, where the two peptides act synergistically — GHRH increases the pool of responsive somatotrophs while the GHRP (Ipamorelin) amplifies the pulse magnitude. The result is a substantially larger GH pulse than either peptide alone.
💉 Dosing Protocol
| Protocol | Dose | Frequency | Timing | Notes |
|---|---|---|---|---|
| Standard (solo) | 100 mcg | 2–3x daily | Fasted | Modest effect without GHRP co-administration |
| Stack (+ Ipamorelin) | 100 mcg CJC + 200–300 mcg Ipa | 2–3x daily | Fasted / pre-sleep | Most studied protocol — synergistic GH pulse |
| High stack | 100–200 mcg CJC + 300 mcg Ipa | 3x daily | Fasted / pre-sleep / post-workout | Upper range in research models |
⚗️ Reconstitution Instructions
- Allow 2mg vial and BAC water to reach room temperature
- Add 2ml BAC water → 1000 mcg/ml concentration
- 100mcg dose = 0.10ml = 10 IU on insulin syringe
- When stacking with Ipamorelin: both can be drawn into the same syringe immediately before injection
- Store at 2–8°C. Use within 30 days.
🔗 Stack Guide: CJC-1295 + Ipamorelin
To stack CJC-1295 with Ipamorelin: reconstitute each peptide separately. At time of injection, draw the Ipamorelin dose first, then draw the CJC-1295 dose into the same syringe. The two are stable together in the syringe for immediate use. Administer as a single subcutaneous injection in a fasted state.
⚠️ Disclaimer
CJC-1295 (no DAC) is a research chemical not approved for human use. Not medical advice. Research purposes only.