Ipamorelin
🔬 Overview
Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist. It stimulates the pituitary gland to release growth hormone in a pulsatile fashion, closely mimicking the body's natural GH release pattern.
Its key differentiator from other GH secretagogues is its selectivity: Ipamorelin stimulates GH release with minimal impact on cortisol, prolactin, or ACTH — side effects commonly seen with earlier generation secretagogues like GHRP-2 and GHRP-6. This selectivity makes it highly valued in research for isolating GH-specific effects.
Ipamorelin is almost invariably studied in combination with a GHRH analogue (typically CJC-1295 no-DAC / Mod GRF 1-29) to produce a synergistic GH pulse — GHRH increases the number of somatotrophs responding while Ipamorelin amplifies the pulse magnitude.
💉 Dosing Protocol
| Protocol | Dose | Frequency | Timing | Notes |
|---|---|---|---|---|
| Low | 100–150 mcg | 2x daily | Fasted / pre-sleep | Introductory research dose |
| Standard | 200–300 mcg | 2–3x daily | Fasted / pre-sleep | Most studied protocol |
| High | 300 mcg | 3x daily | Fasted / pre-sleep / post-workout | Maximum studied dose — diminishing returns above 300mcg per pulse |
⚡ Timing note: GH secretagogues should be administered in a fasted state (2–3 hours after food) to maximise GH pulse. Insulin inhibits GH release. Pre-sleep administration capitalises on the natural GH pulse during slow-wave sleep.
⚗️ Reconstitution Instructions
- Allow 5mg vial and BAC water to reach room temperature
- Wipe vial tops with alcohol swab — allow to dry
- Add 2ml BAC water to 5mg vial → 2500 mcg/ml concentration
- Gently swirl to dissolve — solution is typically clear immediately
- 300mcg dose = 0.12ml = 12 IU on insulin syringe
- Store at 2–8°C. Use within 30 days.
🔗 Stack Compatibility
The Ipamorelin + CJC-1295 (no-DAC) stack is one of the most studied GH-stimulating combinations. CJC-1295 acts as the GHRH signal while Ipamorelin amplifies the pituitary response — the result is a significantly larger and more sustained GH pulse than either peptide alone. The two can be mixed in the same syringe and injected together.
⚠️ Disclaimer
Ipamorelin is a research chemical not approved for human use. All information is for research purposes only. Not medical advice.