Dihexa
🔬 Overview
Dihexa is a small, highly lipophilic compound derived from angiotensin IV, studied for effects on the hepatocyte growth factor system and synapse formation. It is reported to be extremely potent in preclinical models, which is why research doses are small.
Its defining practical feature is that it is not water soluble, so it cannot be handled like a standard peptide.
💉 Research-Reported Dosing
| Protocol | Dose | Frequency | Notes |
|---|---|---|---|
| Research (low) | 5-8 mg | Once daily | Very potent, small amounts |
| Research (upper) | up to ~20 mg | Once daily | Upper cited range, research only |
| Route | Oral or transdermal | Daily | Depends on carrier used |
Figures are drawn from research literature and community protocols. They are not dosing recommendations. Use the dosage calculator to convert any amount into a syringe volume.
⚗️ Reconstitution & Solubility
- Dissolve the powder first in a small volume of a suitable solvent such as pharmaceutical-grade DMSO, PEG-400, or ethanol. DMSO is the most commonly used in research handling
- Warm gently and mix until fully dissolved and clear
- For oral research use, it can be carried in a lipid such as MCT or another oil after the initial solvent step
- For a topical or transdermal preparation, DMSO is often used as both solvent and penetration carrier
- Label the vessel with solvent, concentration, and date. Store cool, dark, and desiccated
📍 Administration
Because it is lipophilic and crosses the blood-brain barrier, dihexa is studied orally or transdermally rather than by simple aqueous injection. The carrier you choose (DMSO, PEG, ethanol, or oil) determines the practical route.
📚 Research Notes
Preclinical research has examined dihexa for synaptogenesis and cognition, reporting high potency relative to other nootropic compounds. Human clinical data is essentially absent, so it should be treated as an early research compound.
⚠️ Safety & Disclaimer
Dihexa is a research chemical with very limited safety data and high reported potency. Solvents such as DMSO carry their own handling cautions and can increase absorption of whatever is dissolved in them. This is not for human use and is not medical advice.